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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: INSR All Species: 13.94
Human Site: Y539 Identified Species: 34.07
UniProt: P06213 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06213 NP_000199.2 1382 156319 Y539 L F Y K E A P Y Q N V T E F D
Chimpanzee Pan troglodytes Q5IS37 825 92786 R14 P A K C S F W R I F L L G S V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542108 1406 159253 Y564 L F Y K E A P Y Q N V T E F D
Cat Felis silvestris
Mouse Mus musculus P15208 1372 155622 Y539 L F Y K E A P Y Q N V T E F D
Rat Rattus norvegicus P15127 1383 156739 N540 Y K E A P Y Q N V T E F D G Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P08941 2311 260942 T1220 F L L N V Q S T S E S Q L F E
Frog Xenopus laevis Q9PVZ4 1362 153727 F549 V H Y K E A P F Q N V T E F D
Zebra Danio Brachydanio rerio NP_001136144 1353 153245 Y527 V L Y K E A P Y K N V T E F D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P09208 2144 239757 P847 A T I V F K D P R A F I G F V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q968Y9 1846 207106 I693 F F K E V P R I D E N M T I E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 22 N.A. 93.5 N.A. 94.5 94.5 N.A. N.A. 21.2 70.4 68.5 N.A. 27.6 N.A. 28.2 N.A.
Protein Similarity: 100 36.3 N.A. 95.5 N.A. 96.6 96.9 N.A. N.A. 35.2 81.7 80.9 N.A. 38.7 N.A. 42.3 N.A.
P-Site Identity: 100 0 N.A. 100 N.A. 100 0 N.A. N.A. 6.6 80 80 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 6.6 N.A. 100 N.A. 100 6.6 N.A. N.A. 13.3 93.3 93.3 N.A. 13.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 10 0 50 0 0 0 10 0 0 0 0 0 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 0 10 0 0 0 10 0 50 % D
% Glu: 0 0 10 10 50 0 0 0 0 20 10 0 50 0 20 % E
% Phe: 20 40 0 0 10 10 0 10 0 10 10 10 0 70 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 20 10 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 10 10 0 0 10 0 10 0 % I
% Lys: 0 10 20 50 0 10 0 0 10 0 0 0 0 0 0 % K
% Leu: 30 20 10 0 0 0 0 0 0 0 10 10 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 10 0 50 10 0 0 0 0 % N
% Pro: 10 0 0 0 10 10 50 10 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 10 0 40 0 0 10 0 0 10 % Q
% Arg: 0 0 0 0 0 0 10 10 10 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 10 0 10 0 10 0 10 0 0 10 0 % S
% Thr: 0 10 0 0 0 0 0 10 0 10 0 50 10 0 0 % T
% Val: 20 0 0 10 20 0 0 0 10 0 50 0 0 0 20 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 50 0 0 10 0 40 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _